José Mourinho’s men have an 89% chance of victory, Microsoft’s search engine has said, which comes after their 4-0 win against Swansea last week.
The result against Leicester will keep them at the top of the table with nine points, with West Brom in second place on goal difference following their predicted win against Stoke.
Watford, Manchester City and Southampton are all expected to win their matches against Brighton, Bournemouth and Huddersfield respectively, slotting them into third, fourth and fifth places.
Tottenham, who lost to Chelsea last weekend, will go in search of their first win at their temporary Wembley home when Burnley travel to the stadium on Saturday.
Bing gives Mauricio Pochettino’s players a 64% chance of winning, in a match where Harry Kane will be hunting for the goal that will take him to a total of 100 goals for the club in all competitions.
Chelsea look set to continue their title defence with a 56% chance of a win against Everton – although Wayne Rooney’s new-found momentum at the Toffees is sure to pose a challenge for the Blues.
Elsewhere in London, Arsenal’s predicted draw against Liverpool will see them drop to 11th place, while Liverpool’s resulting four-point total will place them in 10th.
Further down the table, Swansea City, Bournemouth, Brighton and West Ham are all expected to fill up the bottom four positions after losing their respective matches, with the Hammers remaining at the very bottom of the league with zero points.
Bing creates its predictions using a complex algorithm that analyses player performance.